What is Alzheimer-contributions
Alzheimer-contributions allows to estimate the relative contribution of one out of many variables to the variance explained by a linear model predicting topography of disease biomarkers.
Alzheimer's disease lesions topography
W-maps and regional T-scores computed across 1000 data subsamples
Pathology epicenters estimation
Proxies for epicenters estimated from data
Cross-validated LMG contributions
LMG relative importance analysis and cross-validation combined to produce a robust estimate of regressors contributions
Contributions visualisation
Comprehensive and customisable plotting of cross-validated contributions
Matching on several covariates
Nearest Neighbours matching to balance for demographic covariates
Reference
Bougacha S, Roquet D, Landeau B, Saul E, Naveau M, Sherif S, Bejanin A, Dhenain M, Raj A, Vivien D, Chetelat G. Contributions of connectional pathways to shaping Alzheimer’s disease pathologies. Brain Commun. 2025 Jan 6;7(1):fcae459. doi: 10.1093/braincomms/fcae459. PMID: 39763634; PMCID: PMC11702304.